Spectrophotometric Method Development and Validation for Simultaneous Estimation of Tenofoir disoproxil fumarate and Emtricitabine in Bulk Drug and Tablet Dosage form

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Suhel Patel
U. S. Baghel
P. Rajesh
D. Prabhakar
G. Engla
P. N. Nagar

Abstract

Two simple, accurate, economical and reproducible spectrophotometric methods for simultaneous estimation of two-component drug mixture of Tenofovir disoproxil fumarate and Emtricitabine in bulk and combined tablet dosage form had been developed. The first method employs formation and solving of simultaneous equations using 259 nm and 286 nm as two analytical wavelengths. The second method is absorption ratio method, which uses 286 nm and 247.6 nm as two analytical wavelengths. Both methods were statistically validated according to International Conference on harmonization and recovery studies confirmed the accuracy of the proposed method.

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Section
Review Article