In vitro N1-Amylase Inhibition and Antihyperglycemic Activity of Helicteres isora in Streptozotocin-Induced Rats

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Alok Sharma
M. Vijayakumar
Arti Raj Verma
Md. Talib
M. K. Unnikrishnan
Ch. V. Rao

Abstract

In present study, in vitro N1-amylase inhibition and streptozotocin-induced oxidative stress were used to evaluate hypoglycemic effects of Helicteres isora (sterculiaceae). Antidiabetic treatment with of H. isora extract (100 mg/kg and 250 mg/kg body weight) for three weeks showed significant reduction in thiobarbituriuc acid reactive substances (TBRAS) and glutathione reductase (GSH-R) in both liver and kidney. The treatment with H. isora significantly altered the glutathione (GSH) and GSH-R to be comparable with the control group. H. isora and tolbutamide treated rats showed decreased lipid peroxidation that is associated with increased activity of superoxide dismutase (SOD) and catalase (CAT).The result of this study thus shows that at 1000 N less than g /ml there was maximum inhibition by the H. isora extract (53.75 %). It also possesses moderate antidiabetic activity, but it exhibits potent antioxidant potential in diabetic conditions.

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Review Article